Polydopamine-Lysophosphatidate-Functionalised Titanium: A Novel Hybrid Surface Finish for Bone Regenerative Applications.

摘要: Aseptic loosening of total joint replacements (TJRs) continues to be the main cause implant failures. The socioeconomic impact surgical revisions is hugely significant; in United Kingdom alone, it estimated that £135m spent annually on revision arthroplasties. Enhancing longevity titanium implants will help reduce incidence and overall cost failed devices. In realising development a superior (Ti) technology, we took inspiration from growing interest reactive polydopamine thin films for biomaterial surface functionalisations. Adopting "one-pot" approach, exposed medical-grade mildly alkaline solution dopamine hydrochloride (DHC) supplemented with (3S)1-fluoro-3-hydroxy-4-(oleoyloxy)butyl-1-phosphonate (FHBP), phosphatase-resistant analogue lysophosphatidic acid (LPA). Importantly, LPA selected analogues like FHBP synergistically cooperate calcitriol promote human osteoblast formation maturation. Herein, provide evidence simply immersing Ti aqueous solutions DHC-FHBP afforded was FHBP-Ti at enhancing facile step have taken modify biological performance final finish are appealing properties may attract attention manufacturers future.