Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells.
作者： R D Curran , T R Billiar , D J Stuehr , K Hofmann , R L Simmons
关键词:
摘要: … Additional culture reagents included L-arg HCl (Gibco Laboratories) and NG-monomethyl-L-… the conversion of large quantities of L-arg to nitrogen oxides within hepatocytes (HC). In Mo …
rupress.org
jem.org参考文章(7)
D J Stuehr, C F Nathan, Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells Journal of Experimental Medicine. ,vol. 169, pp. 1543- 1555 ,(1989) , 10.1084/JEM.169.5.1543
John B. Hibbs, Read R. Taintor, Zdenek Vavrin, Elliot M. Rachlin, Nitric oxide: a cytotoxic activated macrophage effector molecule. Biochemical and Biophysical Research Communications. ,vol. 157, pp. 87- 94 ,(1988) , 10.1016/S0006-291X(88)80015-9
R. M. J. Palmer, D. S. Ashton, S. Moncada, Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature. ,vol. 333, pp. 664- 666 ,(1988) , 10.1038/333664A0
Harald H.H.W. Schmidt, Roland Seifert, Eycke Böhme, Formation and release of nitric oxide from human neutrophils and HL-60 cells induced by a chemotactic peptide, platelet activating factor and leukotriene B4 FEBS Letters. ,vol. 244, pp. 357- 360 ,(1989) , 10.1016/0014-5793(89)80562-9
TR Billiar, RD Curran, DJ Stuehr, MA West, BG Bentz, RL Simmons, An L-arginine-dependent mechanism mediates Kupffer cell inhibition of hepatocyte protein synthesis in vitro. Journal of Experimental Medicine. ,vol. 169, pp. 1467- 1472 ,(1989) , 10.1084/JEM.169.4.1467
Michael A. West, Timothy R. Billiar, Ronald D. Curran, Bonnie J. Hyland, Richard L. Simmons, Evidence that rat Kupffer cells stimulate and inhibit hepatocyte protein synthesis in vitro by different mechanisms Gastroenterology. ,vol. 96, pp. 1572- 1582 ,(1989) , 10.1016/0016-5085(89)90529-5
D J Stuehr, M A Marletta, Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma. Journal of Immunology. ,vol. 139, pp. 518- 525 ,(1987)