Nonsteroidal Anti-Inflammatory Drugs

摘要: Pain (dolor), swelling (tumor), erythema (rubor), and warmth (calor), the cardinal features of inflammation, are present in most patients with rheumatic diseases. Therapeutic strategies to reduce inflammation have been used for centuries, beginning botanical treatments both Western Eastern medical traditions (1). The first isolated plant constituent be tested as an anti-inflammatory drug was salicylic acid from willow bark, which chemically altered acetyl improve its pharmacologic properties. Acetyl became “aspirin” 1899, one drugs widely marketed, aspirin remains today. Other that share anti-inflammatory, analgesic, antipyretic properties termed nonsteroidal (NSAIDs), a diverse group compounds (Table 41-1). It established 1971 salicylates other NSAIDs act by blocking synthesis prostaglandins (PGs), products metabolism membrane-associated fatty arachidonic acid. This finding demonstrated conclusively PGs play important role mediating symptoms signs inflammation. However, normal physiology well disease. As consequence, all possess predictable therapeutic adverse effects must understood order use these safely.