An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development.

作者: Laura B. Chopp , Vishaka Gopalan , Thomas Ciucci , Allison Ruchinskas , Zachary Rae

DOI: 10.1016/J.IMMUNI.2020.10.024

关键词:

摘要: … We show marked transcriptomic and epigenomic differences between mouse thymocytes signaled by MHC II- and β2m-dependent agonist ligands, and the conservation of cluster …

参考文章(114)
Jonathan M. Mudge, Jennifer Harrow, Creating reference gene annotation for the mouse C57BL6/J genome assembly Mammalian Genome. ,vol. 26, pp. 366- 378 ,(2015) , 10.1007/S00335-015-9583-X
Maureen A. McGargill, Irene L. Ch'en, Carol D. Katayama, Gilles Pagès, Jacques Pouysségur, Stephen M. Hedrick, Cutting Edge: Extracellular Signal-Related Kinase Is Not Required for Negative Selection of Developing T Cells The Journal of Immunology. ,vol. 183, pp. 4838- 4842 ,(2009) , 10.4049/JIMMUNOL.0902208
Ed Palmer, Negative selection--clearing out the bad apples from the T-cell repertoire. Nature Reviews Immunology. ,vol. 3, pp. 383- 391 ,(2003) , 10.1038/NRI1085
Jason D. Buenrostro, Beijing Wu, Ulrike M. Litzenburger, Dave Ruff, Michael L. Gonzales, Michael P. Snyder, Howard Y. Chang, William J. Greenleaf, Single-cell chromatin accessibility reveals principles of regulatory variation Nature. ,vol. 523, pp. 486- 490 ,(2015) , 10.1038/NATURE14590
Jacob H. Levine, Erin F. Simonds, Sean C. Bendall, Kara L. Davis, El-ad D. Amir, Michelle D. Tadmor, Oren Litvin, Harris G. Fienberg, Astraea Jager, Eli R. Zunder, Rachel Finck, Amanda L. Gedman, Ina Radtke, James R. Downing, Dana Pe’er, Garry P. Nolan, Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis. Cell. ,vol. 162, pp. 184- 197 ,(2015) , 10.1016/J.CELL.2015.05.047
Mark Bix, Neil E. Simister, Janet M. Loring, David H. Raulet, Rudolf Jaenisch, Maarten Zijlstra, β2-Microglobulin deficient mice lack CD4 − 8 + cytolytic T cells Nature. ,vol. 344, pp. 742- 746 ,(1990) , 10.1038/344742A0
Joanne Kwan, Nigel Killeen, CCR7 directs the migration of thymocytes into the thymic medulla. Journal of Immunology. ,vol. 172, pp. 3999- 4007 ,(2004) , 10.4049/JIMMUNOL.172.7.3999
Megan A Luckey, Motoko Y Kimura, Adam T Waickman, Lionel Feigenbaum, Alfred Singer, Jung-Hyun Park, The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling. Nature Immunology. ,vol. 15, pp. 638- 645 ,(2014) , 10.1038/NI.2917
Michael Mingueneau, Taras Kreslavsky, Daniel Gray, Tracy Heng, Richard Cruse, Jeffrey Ericson, Sean Bendall, Matthew H Spitzer, Garry P Nolan, Koichi Kobayashi, Harald Von Boehmer, Diane Mathis, Christophe Benoist, Adam J Best, Jamie Knell, Ananda Goldrath, Vladimir Jojic, Daphne Koller, Tal Shay, Aviv Regev, Nadia Cohen, Patrick Brennan, Michael Brenner, Francis Kim, Tata Nageswara Rao, Amy Wagers, Katherine Rothamel, Adriana Ortiz-Lopez, Natalie A Bezman, Joseph C Sun, Gundula Min-Oo, Charlie C Kim, Lewis L Lanier, Jennifer Miller, Brian Brown, Miriam Merad, Emmanuel L Gautier, Claudia Jakubzick, Gwendalyn J Randolph, Paul Monach, David A Blair, Michael L Dustin, Susan A Shinton, Richard R Hardy, David Laidlaw, Jim Collins, Roi Gazit, Derrick J Rossi, Nidhi Malhotra, Katelyn Sylvia, Joonsoo Kang, Anne Fletcher, Kutlu Elpek, Angelique Bellemare-Pelletier, Deepali Malhotra, Shannon Turley, Immunological Genome Consortium, The transcriptional landscape of αβ T cell differentiation Nature Immunology. ,vol. 14, pp. 619- 632 ,(2013) , 10.1038/NI.2590