Function of NADPH Oxidase 1 in Pulmonary Arterial Smooth Muscle Cells After Monocrotaline-Induced Pulmonary Vascular Remodeling

作者: Florian Veit , Oleg Pak , Bakytbek Egemnazarov , Markus Roth , Djuro Kosanovic

DOI: 10.1089/ARS.2012.4904

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摘要: Abstract Aims: Chronic hypoxia induces pulmonary hypertension (PH) that is concomitant with vascular remodeling. Reactive oxygen species (ROS) are thought to play a major role in this. Recent findings suggest ROS production by NADPH oxidase 4 (Nox4) important this We investigated whether Nox also an inflammatory model of monocrotaline (MCT)-induced PH. examined production, their possible sources, and impact on the function arterial smooth muscle cells (PASMC) isolated from MCT-treated healthy rats. Results: MCT-PASMC showed increased intracellular superoxide migration, proliferation compared controls due Nox1 expression. A comparison PASMC MCT- nontreated rats revealed up-regulation Sod2, Nrf2, cyclin D1, matrix metalloproteinase-9 (MMP-9) as well phosphorylation cofilin extracellular signal-regulated kinases (Erk). Expressi...

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