Hypoxic Roadmap of Glioblastoma-Learning about Directions and Distances in the Brain Tumor Environment.

摘要: Malignant brain tumor-glioblastoma is not only difficult to treat but also hard study and model. One of the reasons for these their heterogeneity, i.e., individual tumors consisting cancer cells that are unlike each other. Such diverse can thrive due simultaneous co-evolution anatomic niches adaption into zones with distorted homeostasis oxygen. It dampens cytotoxic immune therapies as response depends on cellular composition its adaptation hypoxia. We explored what transcriptome reposition strategies used by in different areas tumor. created hypoxic map differential expression analysis between features using RNA sequencing data cross-referenced tumor's (Ivy Glioblastoma Atlas Project). The molecular functions genes differentially expressed regions were analyzed a systematic review gene ontology analysis. To put niche signature clinical context, we associated model patients' survival datasets (The Cancer Genome Atlas). most unique class area tumor was process autophagy. Both enriched whose, along autophagy cluster genes, had power predict glioblastoma patient survival. Our revealed responsive hypoxia predicted worse outcomes driving cell metabolic stress escape.