Dietary Phytochemicals as Epigenetic Modulators in Cancer

摘要: Epigenetics refers to heritable changes in gene expression that are not attributable DNA sequence, but rather depend on alterations methylation, chromatin structure or microRNA profiles. Although epigenetic somatic cells, these modifications potentially reversible and make them attractive promising targets the prevention therapy of cancer. Dietary phytochemicals, especially present fruits, vegetables beverages have recently shown considerable promise affecting via mechanisms. These agents include tea polyphenols, genistein, curcumin, sulforaphane, isothiocynates, lycopene, resveratrol, quercetin, indol-3-carbinol, ellagitannin organosulfur compounds. This chapter discusses impact environment, lifestyle dietary factors presents evidence modulation by phytochemicals is associated with also emphasizes an increased understanding anticancer effects offer new more opportunities for prevention, perhaps