Timing and dose of BCG vaccination in infants as assessed by postvaccination tuberculin sensitivity.

摘要: Tuberculosis is an important public health problem in developing countries and BCG plays role preventing serious form of the disease children. induced tuberculin sensitivity a quantitative characteristic has been used to compare vaccine efficacy. The standard dose 0.1mg 1 ml though manufacturers certain strains BCG, i.e., Copenhagen 1331 recommend half infants. There are also varying ideas about optimum time vaccinate babies some studies suggest that late vaccination confers high degree protection. This study was carried out evaluate side effects following 0.05 0.1 at birth 4-6 weeks age. Two hundred thirty eight newborns were vaccinated randomly with (Copenhagen strain) containing .69 million culturable particles per ml. One infants age BCG. fifty five (44.7%) evaluated by Mantoux test using 1TU PPD RT23 10-12 after 105 (30.6%) followed up till 6 months for any effects. No significant difference mean reaction, positivity scar size observed groups receiving or However, group had significantly lower size. locoregional observed. Hence present practice giving should be continued.