Steady progress and recent breakthroughs in the accuracy of automated genome annotation
作者： Michael R. Brent
DOI: 10.1038/NRG2220
关键词:
摘要: The sequencing of large, complex genomes has become routine, but understanding how sequences relate to biological function is less straightforward. Although much attention focused on annotate genomic features such as developmental enhancers and non-coding RNAs, there still no higher eukaryote for which we know the correct exon-intron structure at least one ORF each gene. Despite this uncomfortable truth, genome annotation made remarkable progress since first drafts human were analysed. By combining several computational experimental methods, are now closer producing complete accurate gene catalogues than ever before.
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