Neural Tube Expression of Pituitary Adenylate Cyclase-Activating Peptide (PACAP) and Receptor: Potential Role in Patterning and Neurogenesis
作者： James A. Waschek , Robert A. Casillas , Thinh B. Nguyen , Emanuel M. DiCicco-Bloom , Ellen M. Carpenter
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摘要: Neural tube patterning in vertebrates is controlled part by locally secreted factors that act a paracrine manner on nearby cells to regulate proliferation and gene expression. We show here situ hybridization genes for the neuropeptide pituitary adenylate cyclase-activating peptide (PACAP) one of its high-affinity receptors (PAC1) are widely expressed mouse neural embryonic day (E) 10.5. Transcripts ligand present differentiating neurons much tube, whereas receptor underlying ventricular zone, most prominently alar region floor plate. PACAP potently increased cAMP levels more than 20-fold cultured E10.5 hindbrain neuroepithelial cells, suggesting activates protein kinase A (PKA) might process patterning. Consistent with this possibility, down-regulated expression sonic hedgehog- PKA-dependent target gli-1 concomitant decrease DNA synthesis. thus an early inducer embryo may during control cell
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