Specific Localization of the Drosophila Telomere Transposon Proteins and RNAs, Give Insight in Their Behavior, Control and Telomere Biology in This Organism

摘要: Drosophila telomeres constitute a remarkable exception to the telomerase mechanism. Although maintaining same cytological and functional properties as maintain telomeres, embed telomere retrotransposons whose specific highly regulated terminal transposition maintains appropriate length in this organism. Nevertheless, our current understanding of how mechanism retrotransposon works which features are shared with system is very limited. We report for first time detailed study localization main components that Drosophila, HeT-A TART RNAs proteins. Our results wild type mutant strains reveal localizations Gag Pol give insight behavior their control. find only co-localize at during interphase cells undergoing mitotic cycles. In addition, unexpected protein RNA well-defined pattern such ovarian border nurse cells, suggest possible strategies transposons reach oocyte, and/or additional functions might be important correct development Finally, we have been able visualize different stages lines, demonstrating presence spite being tightly by piRNA