The genetics of the human circadian clock.

摘要: Daily rhythms of behavioral and physiological processes are believed to arise from endogenous circadian clocks. Unlike model organisms, genetic studies human traits present extra challenges due many factors such as the heterogeneous background environmental influences. Identifying molecular components clock were not possible until recognition Mendelian in subjects recent years. Characterizing these rare therefore established foundation for identification sleep mechanisms. This line investigation has proven fruitful provided new insights into pathways. Genetic association have also offered contributions Studies genes/proteins conjunction with modeling mutations organisms afford opportunity unravel mechanisms which time will lead pharmacological interventions that may only help modify but prove effective treating other sleep-related disorders.