[Eosinophilic esophagitis--pathogenesis, clinical presentation and therapeutic management].

摘要: Eosinophilic esophagitis (EE) is a relatively new, chronic, TH 2-type allergic inflammation of the esophagus. EE occurs more frequently in men. Allergic diseases such as asthma or atopic dermatitis are present 50 - 70 % patients their relatives. In adults, most common presenting symptom dysphagia, with without food bolus impaction. Endoscopic findings include mucosal furrows, corrugated concentric rings ridges esophagus (”feline esophagus”), tiny whitish exudates. The diagnosis confirmed by observation high counts eosinophils esophageal epithelium (at least 24 /HPF). cornerstones medical therapy either topical systemic corticosteroids. Additional therapies included leukotriene receptor antagonists (montelukast) and IL-5 blockers (Mepolizumab). Complications strictures should be carefully dilated using bougies balloon. Currently it still not known whether late complications can prevented use anti-inflammatory agents this only demonstrated through further long-term follow-up studies.