Mechanismen potenziell vasoprotektiver Wirkungen von NO
作者： G. Kojda
DOI: 10.1007/978-3-642-87803-9_3
关键词:
摘要: Die Vasodilatation ist die am besten bekannte Wirkung von NO innerhalb des kardiovaskularen Systems. Vor etwa 20 Jahren hat diese zur Entdeckung EDRF gefuhrt [27]. nachfolgende intensive Forschung konnte dann zeigen, dass endogene NO-Produktion in der Blutgefaswand ein wichtiger physiologischer Faktor fur Regulation lokalen Vasomotion und Blutdrucks [15]. Eine pharmakologische Hemmung endogenen NO-Synthese eine Steigerung beim Menschen zu Folge Disruption eNOS fuhrt Hypertonie Maus [28, 29]. Erhohter Blutdruck gut bekannter Risikofaktor Ausbildung anderer kardiovaskularer Erkrankungen wie Schlaganfall oder Herzinfarkt, wahrend effektive Blutdrucksenkung Verminderung Morbiditat Mortalitat beitragt [30]. Daher kann Aufrechterhaltung eines normalen durch endothelial gebildetes als wichtige vasoprotektive angesehen werden.
springer.com
sci-hub.st 参考文章(144)
Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels The New England Journal of Medicine. ,vol. 339, pp. 1349- 1357 ,(1998) , 10.1056/NEJM199811053391902
HEATHER K. B. SIMMERMAN, LARRY R. JONES, Phospholamban: Protein Structure, Mechanism of Action, and Role in Cardiac Function Physiological Reviews. ,vol. 78, pp. 921- 947 ,(1998) , 10.1152/PHYSREV.1998.78.4.921
M S Wolin, K S Wood, L J Ignarro, Guanylate cyclase from bovine lung. A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme. Journal of Biological Chemistry. ,vol. 257, pp. 13312- 13320 ,(1982) , 10.1016/S0021-9258(18)33448-3
Schwartz Sm, Smooth muscle migration in atherosclerosis and restenosis. Journal of Clinical Investigation. ,vol. 100, pp. 2814- 2817 ,(1997)
T. Scott-Burden, P. M. Vanhoutte, The endothelium as a regulator of vascular smooth muscle proliferation Monograph - American Heart Association. ,vol. 87, ,(1993)
G. Kojda, Therapeutic Importance of Nitrovasodilators Springer, Berlin, Heidelberg. pp. 365- 384 ,(2000) , 10.1007/978-3-642-57077-3_16
R. G. G. Andersson, J. Ahlner, K. Torfgard, K. L. Axelsson, ORGANIC NITRATE ESTERS : CLINICAL USE AND MECHANISMS OF ACTIONS Pharmacological Reviews. ,vol. 43, pp. 351- 423 ,(1991)
R Collins, R Peto, M Flather, S Parish, P Sleight, M Conway, A Pipilis, C Baigent, D Barnett, JP Boissel, A Budaj, J Cairns, L Ceremuzynski, AF Cohen, Gui De Backer, R Diaz, F Dienstl, P Dove, MG Franzosi, M Genoni, DA Halon, J Heikkila, C Hennekens, J Horgan, D Hunt, R Kala, N Karatzas, A Keech, M Keltai, J Kjekshus, M Kornitzer, R Koster, P Landless, P Lechleitner, A Leizorovicz, BS Lewis, L Lundkvist, S Macmahon, A Maggioni, R Malacrida, T Meyer, T Moccetti, D Ocallaghan, E Paolasso, LS Piegas, A Reikvam, P Ridker, T Ryan, R Schroder, R Seabragomes, JEMR Sousa, G Tognoni, A Turpie, V Valentin, J Varigos, H White, L Wilhelmsen, K Woods, S Yusuf, A Piombo, LA Guzman, DC Montenegro, G Irusta, RA Schneider, C Cuneo, BH Chamorro, GE Espinosa, M Moreno, MM Rios, R Doll, K Fox, D Julian, P Meier, E Sandoya, JE Perez, None, ISIS-4 - A randomised factorial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58.050 patient with suspected acute myocardial-infarction. The Lancet. ,vol. 345, pp. 669- 685 ,(1995)
A. Friebe, G. Schultz, D. Koesling, Sensitizing soluble guanylyl cyclase to become a highly CO-sensitive enzyme. The EMBO Journal. ,vol. 15, pp. 6863- 6868 ,(1996) , 10.1002/J.1460-2075.1996.TB01078.X
R Radi, J S Beckman, K M Bush, B A Freeman, Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide. Journal of Biological Chemistry. ,vol. 266, pp. 4244- 4250 ,(1991) , 10.1016/S0021-9258(20)64313-7