Determinants of coronary blood flow in humans: quantification by intracoronary Doppler and ultrasound.

摘要: The direct determinants of coronary flow are lumen area and blood velocity; however, the precise mechanisms that control these factors not fully understood. aim present study was to assess by which velocity interact with hemodynamic morphometric factors, thereby influencing flow. Intracoronary Doppler ultrasound measurements were performed in 28 patients without irregularities. Flow cross-sectional measured proximal segments all three arteries. Global global obtained adding up values Left ventricular mass assessed echocardiography. Stress-mass-heart rate pressure-rate products reflecting myocardial oxygen demand calculated. increased during adenosine-induced hyperemia from 197 +/- 72 637 204 ml/min (P < 0.001). closely correlated stress-mass-heart product (r = 0.62; P Looking at two constituents separately, related left muscle 0.61; 0.001), whereas mean rest showed a strong linear relation 0.64; There no interaction between any vessels. Coronary size velocity, flow, principally determined different physiological factors. Long-term adaptation is achieved an increase size, short-term requirements met changes resting velocity.