Vitamin C supplementation does not alter the immune response to 2.5 hours of running.

作者: David C. Nieman , Dru A. Henson , Diane E. Butterworth , Beverly J. Warren , J. Mark Davis

DOI: 10.1123/IJSN.7.3.173

关键词:

摘要: This randomized, double-blind, placebo-controlled study was designed to determine the influence of vitamin C supplementation on immune response 2.5 hr high-intensity running. Twelve experienced marathon runners (VO2 max 51.6 +/- 1.5 ml.kg-1.min-1, age 40.5 2.0 years) were randomized into (1,000 mg/day for 8 days) or placebo groups. On test day, subjects ran at 75-80% VO2 hr, with five blood samples taken before and 6 after. Blood analyzed cortisol catecholamines; leukocyte subsets; interleukin-6; natural killer cell activity; lymphocyte proliferation as induced by concanavalin A, phytohemagglutinin, pokeweed mitogen; granulocyte phagocytosis activated oxidative burst. Compared placebo, had no significant effect pattern change in any these hormonal measures following intensive

参考文章(27)
K Arabatzis, D C Nieman, L M Johanssen, J W Lee, Infectious episodes in runners before and after the Los Angeles Marathon. Journal of Sports Medicine and Physical Fitness. ,vol. 30, pp. 316- 328 ,(1990)
M. Gleeson, J. D. Robertson, R. J. Maughan, Influence of exercise on ascorbic acid status in man. Clinical Science. ,vol. 73, pp. 501- 505 ,(1987) , 10.1042/CS0730501
R A Jacob, D S Kelley, F S Pianalto, M E Swendseid, S M Henning, J Z Zhang, B N Ames, C G Fraga, J H Peters, Immunocompetence and oxidant defense during ascorbate depletion of healthy men. The American Journal of Clinical Nutrition. ,vol. 54, pp. 1302- 1309 ,(1991) , 10.1093/AJCN/54.6.1302S
R Anderson, R Oosthuizen, R Maritz, A Theron, A J Van Rensburg, The effects of increasing weekly doses of ascorbate on certain cellular and humoral immune functions in normal volunteers The American Journal of Clinical Nutrition. ,vol. 33, pp. 71- 76 ,(1980) , 10.1093/AJCN/33.1.71
R A Jacob, B J Burri, Oxidative damage and defense. The American Journal of Clinical Nutrition. ,vol. 63, ,(1996) , 10.1093/AJCN/63.6.985
W R Beisel, Single nutrients and immunity The American Journal of Clinical Nutrition. ,vol. 35, pp. 417- 468 ,(1982) , 10.1093/AJCN/35.2.417
D. Nieman, S. Simandle, D. Henson, B. Warren, J. Suttles, J. Davis, K. Buckley, J. Ahle, D. Butterworth, O. Fagoaga, S. Nehlsen-Cannarella, Lymphocyte Proliferative Response to 2.5 Hours of Running International Journal of Sports Medicine. ,vol. 16, pp. 404- 409 ,(1995) , 10.1055/S-2007-973028
R. Shephard, P. Shek, Heavy exercise, nutrition and immune function: is there a connection? International Journal of Sports Medicine. ,vol. 16, pp. 491- 497 ,(1995) , 10.1055/S-2007-973043
H Dabrowska, K Dabrowski, K Meyer-Burgdorff, W Hanke, K.-D Gunther, The effect of large doses of vitamin C AND magnesium on stress responses in common carp, Cyprinus carpio Comparative Biochemistry and Physiology Part A: Physiology. ,vol. 99, pp. 681- 685 ,(1991) , 10.1016/0300-9629(91)90150-B