Reduced response of retinal vessel diameters to flicker stimulation in patients with diabetes

摘要: Background/aim: Stimulation of the retina with flickering light increases retinal arterial and venous diameters in animals humans, indicating a tight coupling between neural activity blood flow. The aim present study was to investigate whether this response is altered patients insulin dependent diabetes mellitus. Methods: 26 mellitus no or mild non-proliferative retinopathy age sex matched healthy volunteers were included study. Retinal vessel measured continuously Zeiss analyser. During these measurements three episodes square wave flicker stimulation periods (16, 32, 64 seconds; 8 Hz) applied through illumination pathway Results: In arteries, diffuse luminance significantly diminished diabetic compared (ANOVA, p v baseline), +2.8% (SD 2.2%) (p Conclusion: Flicker responses arteries veins are abnormally reduced IDDM retinopathy. Whether can be attributed vascular reactivity decreased has yet clarified.