Combination chemotherapy versus melphalan and prednisolone in the treatment of multiple myeloma: an overview of published trials.

摘要: PURPOSEA meta-analysis was performed to compare survival after treatment with melphalan and prednisolone (M + P) that combination chemotherapy (CCT) in patients multiple myeloma.METHODSMeta-analysis on 18 published trials comprising 3,814 comparing M P CCT. Two-year percentages observed expected deaths at 2 years were calculated for each trial, the overview methodology applied these figures.RESULTSOverall results from suggest there is no difference efficacy between two treatments. This finding, however, masks a highly significant correlation 2-year rates P-treated individual studies CCT study (r = .69; .0008). In separate overviews, those high rate showed favor of (P .02), whereas low suggested i...