Abnormal spontaneous brain activity in type 2 diabetic retinopathy revealed by amplitude of low-frequency fluctuations: a resting-state fMRI study.

摘要: Aim To explore the altered spontaneous cerebral activity patterns and impaired functional regions in patients with diabetic retinopathy (DR) using resting-state magnetic resonance imaging (rs-fMRI) based on amplitude of low-frequency fluctuations (ALFF) algorithm. Materials methods Twenty-one DR (mean age, 54.9±9.9 years; 11 females) 17 healthy control subjects (54.8±5.7 9 were prospectively studied. The underwent laboratory tests. All individuals a neuropsychological test. differences ALFF values between two groups compared. relationships clinical measurements analysed multiple-factor analysis. Results Compared to controls, group showed significantly increased bilateral occipital gyrus, right lingual precuneus, decreased posterior/anterior cerebellar lobe parahippocampal, fusiform, superior temporal, inferior parietal, angular gyrus. Furthermore, Montreal Cognitive Assessment (MoCA) scores negatively correlated group, while precuneus gyrus found be positively glycosylated haemoglobin (HbA1c) levels. Conclusions Patients abnormalities many that associated cognitive impairments. HbA1c levels patients.