Evans Blue Might Produce Pathologically Activated Neuroprotective Effects via the Inhibition of the P2X4R/p38 Signaling Pathway

Wei Cui, Zaijun Zhang, Wenming Li, Shengquan Hu, Shinghung Mak, Huan Zhang, Renwen Han, Shuai Yuan, Sai Li, Fei Sa, Daping Xu, Zhixiu Lin, Zhong Zuo, Jianhui Rong, Edmond Dik-Lung Ma, Tony Chunglit Choi, Simon MY Lee, Yifan Han, The anti-cancer agent SU4312 unexpectedly protects against MPP+-induced neurotoxicity via selective and direct inhibition of neuronal NOS British Journal of Pharmacology. ,vol. 168, pp. 1201- 1214 ,(2013) , 10.1111/BPH.12004

Christoph Kleinschnitz, Felix Fluri, Michael Schuhmann, Animal models of ischemic stroke and their application in clinical research. Drug Design Development and Therapy. ,vol. 9, pp. 3445- 3454 ,(2015) , 10.2147/DDDT.S56071

Lauriane Ulmann, Françoise Levavasseur, Elena Avignone, Ronan Peyroutou, Hélène Hirbec, Etienne Audinat, François Rassendren, Involvement of P2X4 receptors in hippocampal microglial activation after status epilepticus. Glia. ,vol. 61, pp. 1306- 1319 ,(2013) , 10.1002/GLIA.22516

Aristeidis A. Kritis, Eleni G. Stamoula, Krystallenia A. Paniskaki, Theofanis D. Vavilis, Researching glutamate - induced cytotoxicity in different cell lines: a comparative/collective analysis/study Frontiers in Cellular Neuroscience. ,vol. 9, pp. 91- 91 ,(2015) , 10.3389/FNCEL.2015.00091

Guerrero-Alba Raquel, Valdez-Morales Eduardo, Espinosa-Luna Rosa, Jiménez-Vargas Nestor, Liñan-Rico Andrómeda, Díaz-Hernández Verónica, Barajas-López Carlos, None, P2X4 subunits are part of P2X native channels in murine myenteric neurons European Journal of Pharmacology. ,vol. 709, pp. 93- 102 ,(2013) , 10.1016/J.EJPHAR.2013.03.045

Birgit Obermeier, Richard Daneman, Richard M Ransohoff, Development, maintenance and disruption of the blood-brain barrier Nature Medicine. ,vol. 19, pp. 1584- 1596 ,(2013) , 10.1038/NM.3407

Isabelle Martins, Antoine Tesniere, Oliver Kepp, Mickael Michaud, Frederic Schlemmer, Laura Senovilla, Claire Séror, Didier Métivier, Jean-Luc Perfettini, Laurence Zitvogel, Guido Kroemer, Chemotherapy induces ATP release from tumor cells. Cell Cycle. ,vol. 8, pp. 3723- 3728 ,(2009) , 10.4161/CC.8.22.10026

Tian-tian Zhou, Jing-ru Wu, Zi-yang Chen, Zhen-xiu Liu, Bei Miao, Effects of dexmedetomidine on P2X4Rs, p38-MAPK and BDNF in spinal microglia in rats with spared nerve injury Brain Research. ,vol. 1568, pp. 21- 30 ,(2014) , 10.1016/J.BRAINRES.2014.04.025

Chikako Nito, Hiroshi Kamada, Hidenori Endo, Kuniyasu Niizuma, D Jeannie Myer, Pak H Chan, Role of the p38 mitogen-activated protein kinase/cytosolic phospholipase A2 signaling pathway in blood-brain barrier disruption after focal cerebral ischemia and reperfusion. Journal of Cerebral Blood Flow and Metabolism. ,vol. 28, pp. 1686- 1696 ,(2008) , 10.1038/JCBFM.2008.60

Stuart A. Lipton, Pathologically activated therapeutics for neuroprotection Nature Reviews Neuroscience. ,vol. 8, pp. 803- 808 ,(2007) , 10.1038/NRN2229