An Evaluation of Synapse Independence

摘要: If, as is widely believed, information stored in the brain distributed modifications of synaptic efficacy, it can be argued that storage capacity will maximized if number synapses operate independently large possible. The majority are glutamatergic; their independence compromised glutamate released at one synapse significantly activate receptors neighboring synapses. There currently no agreement on whether “spillover” after liberation a vesicle To evaluate central synapses, necessary to compare responses with those generated by spillover. Here, activation and spillover simulated model, based data for hippocampal includes an approximate representation extrasynaptic space. Recently-published transporter distribution properties incorporated. Factors likely influence or investigated. For release vesicle, estimated mean response nearest