Predictors of mucoid Pseudomonas colonization in cystic fibrosis patients.

摘要: Rationale Chronic mucoid Pseudomonas aeruginosa within the airway in cystic fibrosis (CF) patients can determine prognosis. Understanding risk factors of P. acquisition may change how we deliver care. This study aims to evaluate whether presence reported predict disease severity including gender, CFTR genotype, bacterial organisms cultures, and serum levels vitamins A E, albumin, C-reactive protein, alpha 1-antitrypsin, immunoglobulins increased acquisition. Methods Primary endpoint was age at first transition from negative positive culture for aeruginosa. Cox proportional hazards regression with time-dependent covariates examined development infection its association longitudinally measured biomarkers, pulmonary function, results other organisms. Results Median ages CF diagnosis were 0.55 5.7 years, respectively. Median number cultures/patient 17. Of 323 subjects, 150 developed during a median 8.1 years' follow-up. In multivariate analysis, gender (relative hazard [RH] male vs. female, P = 0.001), DF508 alleles (RH 1.66 1 or 2 0, P = 0.04), FEV1 % 1.16 10% decrease, P = 0.008), most recent Staphylococcus aureus status 0.24 negative, P < 0.0001) remained statistically significant. Conclusion Female alleles, decreased lung lack S. on sputum are important early detection Pediatr Pulmonol. 2008; 43:463–471. © 2008 Wiley-Liss, Inc.