Functional Ser205Leu polymorphism of the nerve growth factor receptor (NGFR) gene is associated with vagal autonomic dysregulation in humans

摘要: Evidence indicates that reduced cardiac vagal (parasympathetic) tone, a robust cardiovascular risk factor, is trait vulnerability marker of major depressive disorder (MDD). The Ser205/Ser205 genotype the functional polymorphism (Ser205Leu) nerve growth factor receptor (NGFR), also called p75 neurotrophin (p75NTR), gene reported to increase MDD. Here, we hypothesized NGFR Ser205Leu may have an effect on control. A sample 810 healthy, drug-free, unrelated Han Chinese (413 males, 397 females; mean age 35.17 ± 8.53 years) was included in genotyping. Short-term heart rate variability (HRV) used assess vagus-mediated autonomic function. Potential HRV covariates, such as mood/anxiety status and serum metabolic parameters, were assessed. Homozygotes Ser205 allele had significantly lower high frequency power root square successive heartbeat interval differences, both indices modulation, compared Leu205 carriers. Even after adjusting for relevant confounders, these associations remained significant. Further stratification by sex revealed observed only males. Our results implicate decreased parasympathetic activity associated with gender-specific manner, suggesting potential role modulating