Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice

摘要: Anxiety and fear are normal emotional responses to threatening situations. In human anxiety disorders-such as panic disorder, obsessive-compulsive post-traumatic stress social phobia, specific phobias generalized disorder-these exaggerated. The molecular mechanisms involved in the regulation of pathological mostly unknown. However, availability different inbred strains mice offers an excellent model system which study genetics certain behavioural phenotypes 1-3 . Here we report, using a combination analysis six mouse with quantitative gene expression profiling several brain regions, identification 17 genes patterns that correlate anxiety-like phenotypes. To determine if two genes, glyoxalase 1 glutathione reductase 1, have causal role genesis anxiety, performed genetic manipulation lentivirus-mediated transfer. Local overexpression these resulted increased behaviour, while local inhibition by RNA interference decreased behaviour. Both oxidative metabolism, linking this pathway anxiety-related