Assessing the Proteomic Activity of the Venom of the Ant Ectatomma tuberculatum (Hymenoptera: Formicidae: Ectatomminae)

摘要: Ectatomma tuberculatum has one of the most toxic venoms known among ants but there is no detailed study on its characteristics. In light this, knowing venom’s chemical composition paramount importance in order to obtain information about mechanisms components. Several bioactive molecules have already been identified Hymenoptera venoms, i.e., proteins such as phospholipases, hyaluronidases, and proteinases, well peptides. Protein databases show that protein components ant recently growing exponentially. this study, we from venom by means 2D PAGE, followed tandem nanochromatography with mass spectrometry. A total 48 were identified, which 42 are involved metabolic processes, transport, structural support. Moreover, six them similarity not yet characterized proteins. Nine related attack/defense or maintenance process colony (colony asepsis, conservation constituents, diffusion prey, paralysis alteration homeostasis, cellular toxicity). Our findings may contribute identification new natural prototypes be synthesized used several areas pharmacology.