Dynamic changes in plasma tissue plasminogen activator, plasminogen activator inhibitor-1 and beta-thromboglobulin content in ischemic stroke.

摘要: The aim of this paper is to investigate the corresponding variations plasma tissue plasminogen activator (t-PA) and inhibitor-1 (PAI-1) activities, beta-thromboglobulin (β-TG) content in patients during different stages ischemic stroke. Ischemic stroke a common disease among aging people its occurrence associated with abnormalities fibrinolytic system platelet function. However, few reports focus on dynamic changes β-TG Patients were divided into three groups: acute, convalescent chronic. Plasma t-PA PAI-1 activities determined by chromogenic substrate analysis was detected radioimmunoassay. acute stage had significantly increased levels activity content, but decreased. Negative correlations found between There significant differences aged control group, as well chronic groups. It can be speculated that result compensatory function, increase level not only implies presence likely cause During later stroke, greater attention required monitoring PAI-1.