Familial concordance for age at menarche: analyses from the Breakthrough Generations Study.

摘要: P>Morris DH, Jones ME, Schoemaker MJ, Ashworth A, Swerdlow AJ. Familial concordance for age at menarche: analyses from the Breakthrough Generations Study. Paediatric and Perinatal Epidemiology 2011; 25: 306-311. Age menarche is correlated within families, but estimates of heritability menarcheal have a wide range (0.45-0.95). We examined familial resemblance extent to which this due genetic shared environmental factors. Between 2003 2010 data were retrospectively collected by questionnaire participants UK-based These included 25 970 female aged 16-98 with least one relative who was also study participant. A woman's significantly delayed each yearly increase in her monozygotic twin (average = 7.2 months, P < 0.001), dizygotic 3.0 0.03), older sister 3.3 mother 3.4 maternal grandmother 1.5 0.04), aunt 1.4 0.001) paternal 0.001). There not significant association between ages half-sister pairs or grandmother-granddaughter pairs, based on small numbers. Heritability estimated as 0.57 [95% confidence interval 0.53, 0.61]. Shared factors did an effect model. In conclusion, approximately half variation attributable additive effects remainder non-shared effects.