ASSAY FOR METHYLATION IN THE GST-Pi GENE
作者： Susan Joy Clark , Peter Laurence Molloy , Douglas S. Millar
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摘要: A diagnostic or prognostic assay is disclosed for a disease of condition characterized by abnormal methylation cytosine at side sites within the glutathione-S-transferase (GST) Pi gene and/or its regulatory flanking sequences (e.g., prostate cancer and liver cancer). The comprises: (i) isolating DNA from said subject, (ii) determining selective PCR amplification) presence site GST-Pi sequences.
lens.org 参考文章(32)
Elizabeth E. Cameron, Stephen B. Baylin, James G. Herman, p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing. Blood. ,vol. 94, pp. 2445- 2451 ,(1999) , 10.1182/BLOOD.V94.7.2445.419K19_2445_2451
Roger L. P. Adams, Roy H. Burdon, Molecular biology of DNA methylation ,(1985)
Graham R Taylor, None, Laboratory Methods for the Detection of Mutations and Polymorphisms in DNA ,(1997)
William B. Isaacs, William G. Nelson, Wen-Hsiang Lee, Genetic diagnosis of prostate cancer ,(1995)
J. P. Jost, H. P. Saluz, DNA Methylation: Molecular Biology and Biological Significance Birkhäuser. ,(1993)
Robert Shapiro, Barbara Braverman, Judith B. Louis, Robert E. Servis, Nucleic Acid Reactivity and Conformation Journal of Biological Chemistry. ,vol. 248, pp. 4060- 4064 ,(1973) , 10.1016/S0021-9258(19)43838-6
J. Michael Glendening, Christina M. Bender, Jane W. Fountain, Peter A. Jones, José F. Flores, Nicholas K. Hayward, Mark L. Gonzalgo, Graeme J. Walker, Graeme J. Walker, Edward H. You, Low frequency of p16/CDKN2A methylation in sporadic melanoma: comparative approaches for methylation analysis of primary tumors. Cancer Research. ,vol. 57, pp. 5336- 5347 ,(1997)
Peter M. Warnecke, Paul C. Vincent, Marianne Frommer, Susan J. Clark, Clare Stirzaker, Douglas S. Millar, Cheryl L. Paul, Janet Harrison, Extensive DNA Methylation Spanning the Rb Promoter in Retinoblastoma Tumors Cancer Research. ,vol. 57, pp. 2229- 2237 ,(1997)
Mutsumi Ohe-Toyota, Minoru Toyota, Stephen B. Baylin, Jean Pierre J. Issa, Jean Pierre J. Issa, Coty Ho, Inactivation of CACNA1G, a T-type calcium channel gene, by aberrant methylation of its 5' CpG island in human tumors. Cancer Research. ,vol. 59, pp. 4535- 4541 ,(1999)
John R. Melki, Paul C. Vincent, Susan J. Clark, Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia. Cancer Research. ,vol. 59, pp. 3730- 3740 ,(1999)