What's so special about the developing immune system?

摘要: The evolution of the subdiscipline developmental immunotoxicology (DIT) as it exists today has been shaped by significant regulatory pressures well key scientific advances. This review considers role played legislation to protect children's health, and on emergence immunotoxcity immunotoxicity guidelines, providing some context need for special attention DIT considering evidence that developing immune system may have unique susceptibilities when compared adult system. Understanding full extent this potential complicated a paucity data detailing development during critical life stages complexities comparisons across species. Notably, there are differences between humans nonhuman species used in toxicity testing include specific relative timing more general anatomic differences, these must be factored into interpretation studies. Likewise, understanding how impacts various parameters is design studies, most extensively characterized date young animals. Other factors important DIT, which considered review, recognition effects other than suppression (e.g., allergy autoimmunity) important; improve our assess humans; pathology studies test latter point receives emphasis because evaluations major component standard nonclinical toxicology could serve an evaluate DIT. possibility very consistent with recommendations incorporate evaluation reproductive (DART) protocols. overall objective provide 'snapshot' current state-of-the-science Despite progress, still evolving hope will advance science.