Stability of fentanyl citrate in glass and plastic containers and in a patient-controlled delivery system

摘要: This study determined the stability of fentanyl citrate stored in glass or polyvinyl chloride containers and concentrations delivered by Janssen on-demand analgesic computer (ODAC) system. Solutions containing 500 micrograms (10 mL) were added to 100-mL three each 5% dextrose injection 0.9% sodium injection. All under usual light conditions at room temperature. Samples taken immediately 0.25, 0.5, 1, 6, 12, 24, 36, 48 hours. To determine concentration via ODAC system, 2500 (50 was a 500-mL bag The solution connected samples bolus demand doses collected various times during 30-hour period. assayed stability-indicating gas-liquid chromatographic method. For both plastic containers, mean +/- S.D. recovery after hours 98.6 2.3% when drug diluted 97 1.5% There no significant difference between amount recovered from containers. Nor there any solutions injection.(ABSTRACT TRUNCATED AT 250 WORDS)