MANF regulates dopaminergic neuron development in larval zebrafish.
作者： Y.-C. Chen , M. Sundvik , S. Rozov , M. Priyadarshini , P. Panula
DOI: 10.1016/J.YDBIO.2012.07.030
关键词:
摘要: Mesencephalic astrocyte derived neurotrophic factor (MANF) is recognized as a dopaminergic factor, which can protect neurons from neurotoxic damage. However, little known about the function of MANF during vertebrate development. Here, we report that expression widespread embryonic development and in adult organs analyzed by qPCR situ hybridization zebrafish. Knockdown with antisense splice-blocking morpholino oligonucleotides resulted no apparent abnormal phenotype. Nevertheless, dopamine level morphants was lower than wild type larvae, levels two tyrosine hydroxylase gene transcripts were decreased decrease neuron number certain groups th1 th2 cells diencephalon region observed. These defects rescued injection exogenous manf mRNA. Strikingly, mRNA could partly restore positive Nr4a2-deficient larvae. results suggest involved regulation system
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sci-hub.se 参考文章(59)
Yu-Chia Chen, Madhusmita Priyadarshini, Pertti Panula, Complementary developmental expression of the two tyrosine hydroxylase transcripts in zebrafish Histochemistry and Cell Biology. ,vol. 132, pp. 375- 381 ,(2009) , 10.1007/S00418-009-0619-8
José A. Botella, Florian Bayersdorfer, Florian Gmeiner, Stephan Schneuwly, Modelling Parkinson’s Disease in Drosophila NeuroMolecular Medicine. ,vol. 11, pp. 268- 280 ,(2009) , 10.1007/S12017-009-8098-6
Päivi Lindholm, Johan Peränen, Jaan-Olle Andressoo, Nisse Kalkkinen, Zaal Kokaia, Olle Lindvall, Tõnis Timmusk, Mart Saarma, MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain. Molecular and Cellular Neuroscience. ,vol. 39, pp. 356- 371 ,(2008) , 10.1016/J.MCN.2008.07.016
Alida Filippi, Julia Mahler, Jörn Schweitzer, Wolfgang Driever, Expression of the paralogous tyrosine hydroxylase encoding genes th1 and th2 reveals the full complement of dopaminergic and noradrenergic neurons in zebrafish larval and juvenile brain. The Journal of Comparative Neurology. ,vol. 518, pp. 423- 438 ,(2010) , 10.1002/CNE.22213
V Sallinen, V Torkko, M Sundvik, I Reenilä, D Khrustalyov, J Kaslin, P Panula, MPTP and MPP+ target specific aminergic cell populations in larval zebrafish. Journal of Neurochemistry. ,vol. 108, pp. 719- 731 ,(2009) , 10.1111/J.1471-4159.2008.05793.X
Alida Filippi, Katrin Dürr, Soojin Ryu, Marc Willaredt, Jochen Holzschuh, Wolfgang Driever, Expression and function of nr4a2, lmx1b, and pitx3 in zebrafish dopaminergic and noradrenergic neuronal development BMC Developmental Biology. ,vol. 7, pp. 135- 135 ,(2007) , 10.1186/1471-213X-7-135
Toru Yasuda, Hideki Mochizuki, Use of growth factors for the treatment of Parkinson's disease. Expert Review of Neurotherapeutics. ,vol. 10, pp. 915- 924 ,(2010) , 10.1586/ERN.10.55
J. Jankovic, S. Chen, W.D. Le, The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease. Progress in Neurobiology. ,vol. 77, pp. 128- 138 ,(2005) , 10.1016/J.PNEUROBIO.2005.09.001
Jeehye Park, Sung Bae Lee, Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim, Jongkyeong Chung, None, Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin Nature. ,vol. 441, pp. 1157- 1161 ,(2006) , 10.1038/NATURE04788
Christine Thisse, Bernard Thisse, High-resolution in situ hybridization to whole-mount zebrafish embryos Nature Protocols. ,vol. 3, pp. 59- 69 ,(2008) , 10.1038/NPROT.2007.514