A model of signal processing at the isolated hair cell of the frog semicircular canal

摘要: A computational model has been developed to simulate the electrical behavior of type II hair cell dissected from crista ampullaris frog semicircular canals. In its basolateral membrane, it hosts a system four voltage-dependent conductances (gA, gKV, gKCa, gCa). The conductance was mathematically described using original patch-clamp experimental data. transient K current, IA, isolated as difference between currents obtained before and after removing IA inactivation. remaining IKD, results summation IKV, voltage-calcium-dependent IKCa, calcium ICa. IKD modeled single lumped since physiological role each component is actually not discernible. To gain clear understanding prominent in sustaining transmitter release at cytoneural junction, ICa under different conditions. includes description voltage- time-dependent kinetics for current. After imposing any starting holding potential, sets pertinent values variables continually updates them response variations membrane potential. reconstructs individual I-V curves voltage-clamp experiments simulations compare favorably with proves useful describing early steps signal processing that interaction apical receptor current conductances. program thus helpful aspects sensory transduction are hard analyze native ampullaris.