Acne pathogenesis: history of concepts.

摘要: From the first reliable descriptions of acne in early 19th century, dermatologists recognized it as a disease pilosebaceous follicle. Until middle 20th they hypothesized that seborrhoea, follicular keratosis and microorganisms could be individually responsible for lesions. Inflammation was only regarded final inescapable step process. Although importance these factors has been reevaluated, recent works still them mandatory. In 1970s, onset isotretinoin dramatically improved management. It also provided great opportunities better understanding pathogenic acne. This study analyzes their genesis development from seminal contributions until advances.