Value of rilmenidine therapy and its combination with perindopril on blood pressure and left ventricular hypertrophy in patients with essential hypertension (VERITAS).
作者： Csaba Farsang , Mária Lengyel , Sarolta Borbás , Ágnes Zorándi , Bernadett Szórádi Dienes
DOI: 10.1185/030079903125001659
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摘要: SUMMARYObjectives: The primary objective was to assess the effects of rilmenidine monotherapy and in combination with perindopril on blood pressure (BP) patients assessed grade 1 or 2 essential hypertension. study also examined 2-year left ventricular hypertrophy (LVH) diastolic function ventricle, along mass index hypertensive no LVH, relationship between BP reduction any change LVH.Research design methods: Mild-to-moderate (n = 500) were enrolled a multicentre open treated (1-2 mg per day) plus (2, 4 8 mg if control hypertension not achieved within 12 weeks. Blood recorded at regular intervals by investigators LVH measured centralised single-blind echocardiographic reading.Resul...
sci-hub.se 参考文章(50)
How reliable are serial echocardiographic measurements in detecting regression in left ventricular hypertrophy and changes in function Journal of the American College of Cardiology. ,vol. 34, pp. 1633- ,(1999) , 10.1016/S0735-1097(99)00399-X
Lincoln Edwards, Daniel Fishman, Peleg Horowitz, Nicole Bourbon, Mark Kester, Paul Ernsberger, The I1-imidazoline receptor in PC12 pheochromocytoma cells activates protein kinases C, extracellular signal-regulated kinase (ERK) and c-jun N-terminal kinase (JNK) Journal of Neurochemistry. ,vol. 79, pp. 931- 940 ,(2008) , 10.1046/J.1471-4159.2001.00632.X
P Bousquet, J Feldman, J Schwartz, Central cardiovascular effects of alpha adrenergic drugs: differences between catecholamines and imidazolines. Journal of Pharmacology and Experimental Therapeutics. ,vol. 230, pp. 232- 236 ,(1984)
C Farsang, J Kapocsi, Imidazoline receptors: from discovery to antihypertensive therapy (facts and doubts) Brain Research Bulletin. ,vol. 49, pp. 317- 331 ,(1999) , 10.1016/S0361-9230(99)00057-X
Philip R. Liebson, Greg A. Grandits, Sinda Dianzumba, Ronald J. Prineas, Richard H. Grimm, James D. Neaton, Jeremiah Stamler, Comparison of five antihypertensive monotherapies and placebo for change in left ventricular mass in patients receiving nutritional-hygienic therapy in the Treatment of Mild Hypertension Study (TOMHS). Circulation. ,vol. 91, pp. 698- 706 ,(1995) , 10.1161/01.CIR.91.3.698
BART L. TROY, JOAQUIN POMBO, CHARLES E. RACKLEY, Measurement of Left Ventricular Wall Thickness and Mass by Echocardiography Circulation. ,vol. 45, pp. 602- 611 ,(1972) , 10.1161/01.CIR.45.3.602
Martin C. Michel, Paul A. Insel, Are there multiple imidazoline binding sites Trends in Pharmacological Sciences. ,vol. 10, pp. 342- 344 ,(1989) , 10.1016/0165-6147(89)90002-3
Beverly H. Lorell, Blase A. Carabello, Left Ventricular Hypertrophy Pathogenesis, Detection, and Prognosis Circulation. ,vol. 102, pp. 470- 479 ,(2000) , 10.1161/01.CIR.102.4.470
Jadwiga Szlachcic, Julio F. Tubau, Carol Vollmer, Barry M. Massie, Effect of diltiazem on left ventricular mass and diastolic filling in mild to moderate hypertension The American Journal of Cardiology. ,vol. 63, pp. 198- 201 ,(1989) , 10.1016/0002-9149(89)90285-3
Richard B. Devereux, Vittorio Palmieri, Jennifer E. Liu, Kristian Wachtell, Jonathan N. Bella, Kurt Boman, Eva Gerdts, Markku S. Nieminen, Vasilios Papademetriou, Björn Dahlöf, Progressive hypertrophy regression with sustained pressure reduction in hypertension: the Losartan Intervention For Endpoint Reduction study Journal of Hypertension. ,vol. 20, pp. 1445- 1450 ,(2002) , 10.1097/00004872-200207000-00033