Old chemotherapy makes a comeback: dual alkylator therapy for pediatric high-grade glioma.

William R. Waud, Lawrence V. Rubinstein, Michael R. Grever, Jacqueline Plowman, Antonis D. Koutsoukos, Timothy D. Moore, Preclinical antitumor activity of temozolomide in mice : efficacy against human brain tumor xenografts and synergism with 1,3-bis(2-chloroethyl)-1-nitrosourea Cancer Research. ,vol. 54, pp. 3793- 3799 ,(1994)

J L Finlay, J M Boyett, A J Yates, J H Wisoff, J M Milstein, J R Geyer, S J Bertolone, P McGuire, J M Cherlow, M Tefft, Randomized phase III trial in childhood high-grade astrocytoma comparing vincristine, lomustine, and prednisone with the eight-drugs-in-1-day regimen. Childrens Cancer Group Journal of Clinical Oncology. ,vol. 13, pp. 112- 123 ,(1995) , 10.1200/JCO.1995.13.1.112

Sameer Agnihotri, Aaron S. Gajadhar, Christian Ternamian, Thierry Gorlia, Kristin L. Diefes, Paul S. Mischel, Joanna Kelly, Gail McGown, Mary Thorncroft, Brett L. Carlson, Jann N. Sarkaria, Geoffrey P. Margison, Kenneth Aldape, Cynthia Hawkins, Monika Hegi, Abhijit Guha, Alkylpurine–DNA–N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients Journal of Clinical Investigation. ,vol. 122, pp. 253- 266 ,(2012) , 10.1172/JCI59334

Roger Stupp, Warren P. Mason, Martin J. van den Bent, Michael Weller, Barbara Fisher, Martin J.B. Taphoorn, Karl Belanger, Alba A. Brandes, Christine Marosi, Ulrich Bogdahn, Jürgen Curschmann, Robert C. Janzer, Samuel K. Ludwin, Thierry Gorlia, Anouk Allgeier, Denis Lacombe, J. Gregory Cairncross, Elizabeth Eisenhauer, René O. Mirimanoff, Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma The New England Journal of Medicine. ,vol. 352, pp. 987- 996 ,(2005) , 10.1056/NEJMOA043330

Richard Spostol, Inta J. Ertel, R. D. T. Jenkin, Carl P. Boesel, Joan L. Venes, Jorge A. Ortega, Audrey E. Evans, William Waral, Denman Hammond, The effectiveness of chemotherapy for treatment of high grade astrocytoma in children: Results of a randomized trial - A report from the Childrens Cancer Study Group Journal of Neuro-oncology. ,vol. 7, pp. 165- 177 ,(1989) , 10.1007/BF00165101

Martin Glas, Caroline Happold, Johannes Rieger, Dorothee Wiewrodt, Oliver Bähr, Joachim P. Steinbach, Wolfgang Wick, Rolf-Dieter Kortmann, Guido Reifenberger, Michael Weller, Ulrich Herrlinger, Long-Term Survival of Patients With Glioblastoma Treated With Radiotherapy and Lomustine Plus Temozolomide Journal of Clinical Oncology. ,vol. 27, pp. 1257- 1261 ,(2009) , 10.1200/JCO.2008.19.2195

Ulrich Herrlinger, Johannes Rieger, Dorothee Koch, Simon Loeser, Britta Blaschke, Rolf-Dieter Kortmann, Joachim P. Steinbach, Thomas Hundsberger, Wolfgang Wick, Richard Meyermann, Ta-Chih Tan, Clemens Sommer, Michael Bamberg, Guido Reifenberger, Michael Weller, Phase II Trial of Lomustine Plus Temozolomide Chemotherapy in Addition to Radiotherapy in Newly Diagnosed Glioblastoma: UKT-03 Journal of Clinical Oncology. ,vol. 24, pp. 4412- 4417 ,(2006) , 10.1200/JCO.2006.06.9104

K. J. Cohen, I. F. Pollack, T. Zhou, A. Buxton, E. J. Holmes, P. C. Burger, D. J. Brat, M. K. Rosenblum, R. L. Hamilton, R. S. Lavey, R. L. Heideman, Temozolomide in the treatment of high-grade gliomas in children: a report from the Children's Oncology Group Neuro-oncology. ,vol. 13, pp. 317- 323 ,(2011) , 10.1093/NEUONC/NOQ191

Dominik Sturm, Hendrik Witt, Volker Hovestadt, Dong-Anh Khuong-Quang, David T.W. Jones, Carolin Konermann, Elke Pfaff, Martje Tönjes, Martin Sill, Sebastian Bender, Marcel Kool, Marc Zapatka, Natalia Becker, Manuela Zucknick, Thomas Hielscher, Xiao-Yang Liu, Adam M. Fontebasso, Marina Ryzhova, Steffen Albrecht, Karine Jacob, Marietta Wolter, Martin Ebinger, Martin U. Schuhmann, Timothy van Meter, Michael C. Frühwald, Holger Hauch, Arnulf Pekrun, Bernhard Radlwimmer, Tim Niehues, Gregor von Komorowski, Matthias Dürken, Andreas E. Kulozik, Jenny Madden, Andrew Donson, Nicholas K. Foreman, Rachid Drissi, Maryam Fouladi, Wolfram Scheurlen, Andreas von Deimling, Camelia Monoranu, Wolfgang Roggendorf, Christel Herold-Mende, Andreas Unterberg, Christof M. Kramm, Jörg Felsberg, Christian Hartmann, Benedikt Wiestler, Wolfgang Wick, Till Milde, Olaf Witt, Anders M. Lindroth, Jeremy Schwartzentruber, Damien Faury, Adam Fleming, Magdalena Zakrzewska, Pawel P. Liberski, Krzysztof Zakrzewski, Peter Hauser, Miklos Garami, Almos Klekner, Laszlo Bognar, Sorana Morrissy, Florence Cavalli, Michael D. Taylor, Peter van Sluis, Jan Koster, Rogier Versteeg, Richard Volckmann, Tom Mikkelsen, Kenneth Aldape, Guido Reifenberger, V. Peter Collins, Jacek Majewski, Andrey Korshunov, Peter Lichter, Christoph Plass, Nada Jabado, Stefan M. Pfister, Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell. ,vol. 22, pp. 425- 437 ,(2012) , 10.1016/J.CCR.2012.08.024

Q. T. Ostrom, H. Gittleman, P. Liao, C. Rouse, Y. Chen, J. Dowling, Y. Wolinsky, C. Kruchko, J. Barnholtz-Sloan, CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011. Neuro-oncology. ,vol. 16, ,(2012) , 10.1093/NEUONC/NOU223