Perfluoroalkyl substances measured in breast milk and child neuropsychological development in a Norwegian birth cohort study.
作者： J. Forns , N. Iszatt , R.A. White , S. Mandal , A. Sabaredzovic
DOI: 10.1016/J.ENVINT.2015.06.013
关键词:
摘要: Perfluoroalkyl substances (PFASs) are chemicals with potential neurotoxic effects although the current evidence is still limited. This study investigated association between perinatal exposure to perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic (PFOA) neuropsychological development assessed at 6, 12 24 months. We measured PFOS PFOA in breast milk samples collected one month after delivery by mothers of children participating HUMIS (Norway). Cognitive psychomotor was 6 months using Ages Stages Questionnaire (ASQ-II). Behavioral infant-toddler symptom checklist (ITSC) Weighted logistic regression weighted negative binomial models were applied analyze associations PFASs ASQ-II ITSC, respectively. The median concentration 110 ng/L, while for 40 ng/L. did not detect an increased risk having abnormal score or Moreover, no consistent increase behavioral problems ITSC questionnaire detected. observed early development. Further longitudinal studies needed confirm these compounds on older children.
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