A field trial of a vaccine against American dermal leishmaniasis.

摘要: A field trial was carried out in the eastern part of State Minas Gerais (Brazil) a vaccine containing killed promastigotes five stocks Leishmania. Tests with Montenegro antigen showed that high proportion vaccinated persons became positive within three months, but circulating antibodies were not detected. those continued to give reactions for up years. Lymphocyte sensitivity tests out, on small sample, years after vaccination and gave no evidence immunological depression. No cases cutaneous or mucocutaneous leishmaniasis occurred area during observations.