Refractory Autoimmune Hepatitis: Beyond Standard Therapy

摘要: Autoimmune hepatitis (AIH) can be difficult to control, particularly in some African-Americans. When standard therapy of prednisone and azathioprine is ineffective or poorly tolerated, alternative therapies are resorted to. We report two patients with AIH who were refractory intolerant therapy. They initially responded a combination tacrolimus MMF, but eventually developed acute flares the disease that had managed sirolimus, one case, rituximab, achieve remission.