摘要: The initial report by Grant et al. [1] that variants in the TCF7L2 gene are strongly associated with risk of developing type 2 diabetes has now been robustly reproduced many other populations. In fact, this contribute more powerfully to than any identified date (see also [2]). Since population-attributable is substantial, we need understand whether causally related diabetes, and if so, what pathogenetic mechanisms are. phenotype individuals carrying susceptibility seems be slightly at odds typical individual risk, BMI reduced relative non-risk rather increased. Virtually all reports have shown impaired insulin secretion following a glucose tolerance test, although degree sensitivity not stringently defined. Using minimal model analysis an IVGTT non-diabetic at-risk individuals, Damcott [3] found both sensitivity. Additional studies characterising detail sensitive techniques will enhance our understanding functions TCF7L2.
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Struan F A Grant, Gudmar Thorleifsson, Inga Reynisdottir, Rafn Benediktsson, Andrei Manolescu, Jesus Sainz, Agnar Helgason, Hreinn Stefansson, Valur Emilsson, Anna Helgadottir, Unnur Styrkarsdottir, Kristinn P Magnusson, G Bragi Walters, Ebba Palsdottir, Thorbjorg Jonsdottir, Thorunn Gudmundsdottir, Arnaldur Gylfason, Jona Saemundsdottir, Robert L Wilensky, Muredach P Reilly, Daniel J Rader, Yu Bagger, Claus Christiansen, Vilmundur Gudnason, Gunnar Sigurdsson, Unnur Thorsteinsdottir, Jeffrey R Gulcher, Augustine Kong, Kari Stefansson, Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes Nature Genetics. ,vol. 38, pp. 320- 323 ,(2006) , 10.1038/NG1732
C. Christodoulides, A. Scarda, M. Granzotto, G. Milan, E. Dalla Nora, J. Keogh, G. De Pergola, H. Stirling, N. Pannacciulli, J. K. Sethi, G. Federspil, A. Vidal-Puig, I. S. Farooqi, S. O’Rahilly, R. Vettor, WNT10B mutations in human obesity Diabetologia. ,vol. 49, pp. 678- 684 ,(2006) , 10.1007/S00125-006-0144-4
Birgit Gustafson, Ulf Smith, Cytokines Promote Wnt Signaling and Inflammation and Impair the Normal Differentiation and Lipid Accumulation in 3T3-L1 Preadipocytes Journal of Biological Chemistry. ,vol. 281, pp. 9507- 9516 ,(2006) , 10.1074/JBC.M512077200
Akio Kanazawa, Syuuichi Tsukada, Akihiro Sekine, Tatsuhiko Tsunoda, Atsushi Takahashi, Atsunori Kashiwagi, Yasushi Tanaka, Tetsuya Babazono, Masafumi Matsuda, Kohei Kaku, Yasuhiko Iwamoto, Ryuzo Kawamori, Ryuichi Kikkawa, Yusuke Nakamura, Shiro Maeda, Association of the Gene Encoding Wingless-Type Mammary Tumor Virus Integration-Site Family Member 5B (WNT5B) with Type 2 Diabetes American Journal of Human Genetics. ,vol. 75, pp. 832- 843 ,(2004) , 10.1086/425340
S. E. Ross, Inhibition of Adipogenesis by Wnt Signaling Science. ,vol. 289, pp. 950- 953 ,(2000) , 10.1126/SCIENCE.289.5481.950
Vladimir Korinek, Nick Barker, Petra Moerer, Elly van Donselaar, Gerwin Huls, Peter J. Peters, Hans Clevers, Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nature Genetics. ,vol. 19, pp. 379- 383 ,(1998) , 10.1038/1270
Lynn M. Boyden, Junhao Mao, Joseph Belsky, Lyle Mitzner, Anita Farhi, Mary A. Mitnick, Dianqing Wu, Karl Insogna, Richard P. Lifton, High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5 The New England Journal of Medicine. ,vol. 346, pp. 1513- 1521 ,(2002) , 10.1056/NEJMOA013444
S. Leah Etheridge, Gary J. Spencer, Deborah J. Heath, Paul G. Genever, Expression Profiling and Functional Analysis of Wnt Signaling Mechanisms in Mesenchymal Stem Cells Stem Cells. ,vol. 22, pp. 849- 860 ,(2004) , 10.1634/STEMCELLS.22-5-849
Fenghua Yi, Patricia L. Brubaker, Tianru Jin, TCF-4 Mediates Cell Type-specific Regulation of Proglucagon Gene Expression by β-Catenin and Glycogen Synthase Kinase-3β Journal of Biological Chemistry. ,vol. 280, pp. 1457- 1464 ,(2005) , 10.1074/JBC.M411487200
S. Cauchi, D. Meyre, C. Dina, H. Choquet, C. Samson, S. Gallina, B. Balkau, G. Charpentier, F. Pattou, V. Stetsyuk, R. Scharfmann, B. Staels, G. Fruhbeck, P. Froguel, Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes. Diabetes. ,vol. 55, pp. 2903- 2908 ,(2006) , 10.2337/DB06-0474