Behavioural effects in mice of subchronic buspirone, ondansetron and tianeptine. I. Social interactions.

摘要: Abstract In a continuation of recent work on effects benzodiazepine (chlordiazepoxide) and selective monoamine reuptake inhibitors (maprotiline fluvoxamine), the current study compares 5-HT 1A receptor partial agonist, buspirone (0.75–3.0 mg/kg), 3 antagonist, ondansetron (0.1–100 μg/kg) novel antidepressant, tianeptine (2.5–10.0 mg/kg). Compounds were given daily to mice for 21 days prior testing subsequent behaviour animals during social interactions was assessed by ethopharmacological procedures. Buspirone, at 0.75 mg/kg, increased immobility reduced occurrence aggressive act, “attack.” At 1.5 3.0 it enhanced olfactory exploration sawdust substrate, but had no effect investigation. Ondansetron duration environmental 0.1 μg/kg, while 100 μg/kg digging in substrate. categories failed induce an anxiolytic-like enhancement Tianeptine produced anxiogenic-like 10 5 mg/kg flight immobility. The relevance these findings is discussed relation reported behavioural actions compounds pharmacotherapy anxiety depression. apparent anxiogenic finding which requires further study.