The Conceptual and Experimental Foundations of Vertebrate Embryonic Cell Adhesion Research

摘要: As embryology underwent its transformation from a descriptive to an experimental science, new research programs began seek causal understanding of the striking morphogenetic changes that had been observed occur during embryogenesis. Whether these underlying forces were intrinsic properties individual cells or whether they some holistic property embryo in toto was question fueled by several sources. On one hand, His (1) hypothesized movements occurred as result unequal growth among different populations which led bending and stretching tissues, much pushing pulling on sheet deformable material could lead production complicated shapes. Roux (2), other claimed have specific positive negative cytotropisms isolated early amphibian embryos. The issue developmental regulation cell-autonomous property, opposed expression special attributes embryos, further exacerbated disparate interpretations (3) Driesch (4) regarding their experiments fate sea urchin blastomeres. While Roux’s interpretation independent cellular development cases not supported later investigation, his methods nevertheless served potent stimulus for investigation behaviors contributed overall program morpho-genesis.