Physiological Regulation of Magnocellular Neurosecretory Cell Activity: Integration of Intrinsic, Local and Afferent Mechanisms

摘要: The hypothalamic supraoptic and paraventricular nuclei contain magnocellular neurosecretory cells (MNCs) that project to the posterior pituitary gland where they secrete either oxytocin or vasopressin (the antidiuretic hormone) into circulation. Oxytocin is important for delivery at birth essential milk ejection during suckling. Vasopressin primarily promotes water reabsorption in kidney maintain body fluid balance, but also increases vasoconstriction. profile of secretion principally determined by pattern action potentials initiated cell bodies. Although it has long been known activity MNCs depends upon afferent inputs relay information on reproductive, osmotic cardiovascular status, recently become clear critically local regulation glial cells, as well intrinsic themselves. Here, we provide an overview recent advances our understanding how extrinsic mechanisms integrate with generate appropriate physiological MNC activity.