Molecular targeting in acute myeloid leukemia.

摘要: Acute myeloid leukemia (AML) is a heterogenous disease associated with distinct genetic and molecular abnormalities. Somatic mutations result in dysregulation of intracellular signaling pathways, epigenetics, apoptosis the cells. Understanding basis for dysregulated processes provides platform design novel targeted therapy AML patients. The effort to devise new has been helped by recent advances methods high-throughput genomic screening availability computer-assisted techniques agents that are predicted specifically inhibit mutant molecules involved these events. In this review, we will provide scientific targeting mechanisms discuss currently being investigated, alone or combination chemotherapy, treating patients AML. Successes ultimately change treatment paradigm disease.