Activity of voriconazole (UK-109,496) against clinical isolates of Aspergillus species and its effectiveness in an experimental model of invasive pulmonary aspergillosis.
作者： M Murphy , E M Bernard , T Ishimaru , D Armstrong
DOI: 10.1128/AAC.41.3.696
关键词:
摘要: Voriconazole, a new azole antifungal agent, showed potent activity against clinical isolates of Aspergillus spp. in vitro. For A. fumigatus, the MIC range was < 0.03 to 0.5 microgram/ml and at which 90% are inhibited 0.25 microgram/ml. In an experimental model invasive pulmonary aspergillosis mimics infection humans, oral voriconazole dosages 30 mg/kg body weight per day significantly delayed or prevented mortality.
sci-hub.se 参考文章(20)
J. D. Meyers, Fungal infections in bone marrow transplant patients. Seminars in Oncology. ,vol. 17, pp. 10- 13 ,(1990)
Vicki A. Morrison, Robert J. Haake, Daniel J. Weisdorf, Non-Candida fungal infections after bone marrow transplantation: risk factors and outcome. The American Journal of Medicine. ,vol. 96, pp. 497- 503 ,(1994) , 10.1016/0002-9343(94)90088-4
Susan M. Grant, Stephen P. Clissold, Fluconazole. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in superficial and systemic mycoses. Drugs. ,vol. 39, pp. 877- 916 ,(1990) , 10.2165/00003495-199039060-00006
David W. Denning, Jeanette Y. Lee, John S. Hostetler, Peter Pappas, Carol A. Kauffman, Daniel H. Dewsnup, John N. Galgiani, John R. Graybill, Alan M. Sugar, Antonino Catanzaro, Harry Gallis, John R. Perfect, Bonita Dockery, William E. Dismukes, David A. Stevens, NIAID mycoses study group multicenter trial of oral itraconazole therapy for invasive aspergillosis The American Journal of Medicine. ,vol. 97, pp. 135- 144 ,(1994) , 10.1016/0002-9343(94)90023-X
David W. Denning, David A. Stevens, Antifungal and Surgical Treatment of Invasive Aspergillosis: Review of 2,121 Published Cases Clinical Infectious Diseases. ,vol. 12, pp. 1147- 1201 ,(1990) , 10.1093/CLINIDS/12.6.1147
Stanton L Gerson, George H Talbot, Shelley Hurwitz, BRIAN L STROM, Edward J Lusk, Peter A Cassileth, Prolonged Granulocytopenia: The Major Risk Factor for Invasive Pulmonary Aspergillosis in Patients with Acute Leukemia Annals of Internal Medicine. ,vol. 100, pp. 345- 351 ,(1984) , 10.7326/0003-4819-100-3-345
J H Jorgensen, G A Alexander, J R Graybill, D J Drutz, Sensitive bioassay for ketoconazole in serum and cerebrospinal fluid. Antimicrobial Agents and Chemotherapy. ,vol. 20, pp. 59- 62 ,(1981) , 10.1128/AAC.20.1.59
H.J. Schmitt, F. Edwards, J. Andrade, Y. Niki, D. Armstrong, Comparison of azoles against aspergilli in vitro and in an experimental model of pulmonary aspergillosis. Chemotherapy. ,vol. 38, pp. 118- 126 ,(1992) , 10.1159/000238951
G. Bodey, B. Bueltmann, W. Duguid, D. Gibbs, H. Hanak, M. Hotchi, G. Mall, P. Martino, F. Meunier, S. Milliken, S. Naoe, M. Okudaira, D. Scevola, J. Wout, Fungal infections in cancer patients: an international autopsy survey. European Journal of Clinical Microbiology & Infectious Diseases. ,vol. 11, pp. 99- 109 ,(1992) , 10.1007/BF01967060
E. M. Bernard, H. J. Donnelly, M. P. Maher, D. Armstrong, Use of a New Bioassay to Study Pentamidine Pharmacokinetics The Journal of Infectious Diseases. ,vol. 152, pp. 750- 754 ,(1985) , 10.1093/INFDIS/152.4.750