Lipid Rafts: New Tools and a New Component
作者： Toshihide Kobayashi , Miwa Takahashi , Yasuko Nagatsuka , Yoshio Hirabayashi
DOI: 10.1248/BPB.29.1526
关键词:
摘要: Lipid rafts are liquid ordered membrane domains enriched with sphingolipids and cholesterol. After 20 years since the proposal of original concept, structure function lipid still obscure. Recently new tools to study have been developed. Lysenin is a sphingomyelin binding protein that specifically recognizes clusters. Poly(ethyleneglycol)-derivatized cholesterol ether (PEG-Chol) non-toxic probe. These probes revealed heterogeneity rafts. The further supported by discovery component, phosphatidylglucoside. Metabolic inhibitors another useful tool. Sulfamisterin addition serine palmitoyltransferase inhibitors. Recent findings uncovered previously unrecognized activity glycosphingolipid synthesis inhibitor, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP).
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