Gasotransmitters in Vascular Complications of Diabetes

摘要: In the past decades three gaseous signaling molecules-so-called gasotransmitters-have been identified: nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S). These gasotransmitters are endogenously produced by different enzymes in various cell types play an important role physiology disease. Despite their specific functions, all share capacity to reduce oxidative stress, induce angiogenesis, promote vasorelaxation. patients with diabetes, a lower bioavailability of is observed when compared healthy individuals. As yet, it unknown whether this reduction precedes or results from diabetes. The increased risk for vascular disease combination extensive clinical, financial, societal burden, calls action either prevent improve treatment complications. Perspective, we present concise overview current data on diabetes potential development progression diabetes-associated microvascular (retinopathy, neuropathy, nephropathy) macrovascular (cerebrovascular, coronary artery, peripheral arterial diseases) Gasotransmitters appear have both inhibitory stimulatory effects course development. This Perspective concludes discussion gasotransmitter-based interventions as therapeutic option.