Comparison of Different Symptom Assessment Scales for Multiple System Atrophy.

摘要: To identify the most sensitive scale for use in clinical trials on multiple system atrophy (MSA), a short and is needed MSA trials. Potential candidates are Unified Rating Scale (UMSARS), Assessment of Ataxia (SARA), Berg Balance (BBS), Health-Related Quality Life (MSA-QoL), Scales Outcomes Parkinson’s Disease–Autonomic questionnaire (SCOPA-AUT). We enrolled patients with from eight hospitals Hokkaido, Japan. Board-certified neurologists assessed each patient at 6-month intervals scored them UMSARS, SARA, BBS, MSA-QoL, SCOPA-AUT. Score changes were evaluated using standardized response mean (SRM). The correlation between disease duration score was examined. first evaluation conducted 85 (60 cerebellar ataxia dominant subtype [MSA-C] 25 Parkinsonism-dominant [MSA-P]). Sixty-nine examined after 6 months 63 12 months. UMSARS Part 4 had largest SRM SARA SRMs MSA-P, shorter group, early-onset group larger than those MSA-C, longer late-onset group. items regarding skilled hand activities, walking, standing relatively large. Our study indicates that (parts 2 4), BBS scales evaluating progression over Items large effectively short-term changes.