Diet-induced obesity leads to alterations in behavior and gut microbiota composition in mice.

摘要: The high prevalence of obesity and associated metabolic disorders are one the major public health problems worldwide. Among main causal factors obesity, excessive consumption food rich in sugar fat stands out due to its energy density. regulation intake relies on hypothalamic control by action several neuropeptides. Excessive hypercaloric diets has impact behavior gut microbiota. In present study, we used a high-sugar (HSB) diet for 12 weeks induce C57BL/6 mice investigate effects microbiota, peptides, behavior. We hypothesize that chronic HSB can change Additionally, also changes microbiota be with transcriptional peptides To evaluate performed sequencing 16S rRNA gene, which demonstrate modulates an increase Firmicutes Actinobacteria phylum decrease Bacteroidetes phylum. real time qPCR revealed HSB-fed presented neuropeptides genes such as Npy, Gal Galr1. Marble-burying Light/dark box tests showed alteration anxiety impulsive behaviors mice. Our data provides evidence induced is alterations behavior, highlighting multifactorial characteristics this disease.