Modeling tailed bacteriophage adsorption: Insight into mechanisms.

摘要: The process of a bacteriophage attaching to its host cell is combination physical diffusion, biochemical surface interactions, and reaction-induced conformational changes in receptor proteins. Local variations the physico-chemical properties medium, phage׳s mode action, physiology also all influence adsorption kinetics. These characteristics can affect specific binding capabilities susceptibility phage attack. Despite complexity this process, describing kinetics population bacteriophages culture cells has been accomplished with relatively simple equations governed by laws mass-action. Many permutations modifications basic set reactions have suggested through years. While no single solution emerges as universal answer, review provides fundamentals current modeling will guide researchers selection valid, appropriate models.