Sex chromosome complement influences functional callosal myelination.

摘要: In addition to androgen differences between males and females, there are genetic that caused by unequal dosage of sex chromosome genes. Using the cuprizone-induced demyelination model, we recently showed surgical gonadectomy adult mice resulted in decreased normal myelination remyelination compared gonadally intact animals, suggesting a supporting role for hormones maintenance myelination. However, inherent persisted even after gonadectomy, with consistently remyelinating lesser extent relative as assayed axon conduction immunohistochemistry. This suggests potential complement mediating differential rates observed females. The present study focuses on impact chromosomes might have these differences. Making use four core-genotype cuprizone-diet induced demyelination/remyelination paradigm, our results demonstrate chromosome-mediated asymmetry XX XY mice. rate functional following cuprizone diet-induced callosal is attenuated animals both gonadal sexes. Importantly, this difference arises only absence circulating confirms process reported earlier group. Because genotype-mediated chromosomal contribution subtle yet significant. To explain difference, propose possible expression myelination-related genes vs. needs be investigated future studies.